Characterization of Calcium Phosphate Cement Inks with Added Poloxamer 407 for Potential Application in 3D Printing

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dc.creatorSarmiento , Maria P.
dc.creatorHernández-Ruiz , Juan F.
dc.creatorRuiz , Jeisson S.
dc.creatorMoreno, Daniel
dc.creatorLópez , María E.
dc.date2022-05-26
dc.date.accessioned2025-10-01T23:52:47Z
dc.description3D printing of biomaterials is a growing technology in the manufacture of grafts suitable for the repair of bone defects with complex geometries. Calcium phosphate cements (CFC) are bioceramics used in orthopedic medicine due to their similarity to the mineral phase of bone, the ability to be molded as a paste and to harden in situ. The 3D printing of CFC would potentialize their application by allowing reconstructive surgeries of defects with complex geometries, however, a limitation is the low injectability of CFCs due to the phase separation that occurs during the injection of the paste. In this work, the implementation of a thermosensitive polymer such as Poloxamer 407 has been studied to generate an injectable ink. Such ink has been formulated to contain 5% of carbonated hydroxyapatite type B as a biocompatible and biodegradable nucleating agent. Additions of 0 %, 20 % and 40 % Wt aqueous solutions of Poloxamer 407 were evaluated as gel phase at a liquid/powder ratio of 0.75 mL/g. The injectability coefficient, the cohesion of the inks and the compressive strength of the cements using Weibull´s analysis were implemented, determining that the addition of polymer decreases the mechanical properties of the CFC by 52.68 % and 81.23 %, respectively with relation to the control CFC (0%), attributed to a lower densification of the cement. It was concluded that the additions of Poloxamer 407 do not interfere in the precipitation of calcium-deficient hydroxyapatite nor in the in vitro degradation of cements and favors the ink behavior for its possible implementation in 3D printing.en-US
dc.descriptionLa impresión 3D de biomateriales es una tecnología de gran auge para la fabricación de injertos aptos para la reparación de defectos óseos con geometrías complejas. Los cementos de fosfato de calcio (CFC) son biocerámicos empleados en la medicina ortopédica debido a su similitud con la fase mineral del hueso, la capacidad para ser moldeados como una pasta y endurecer in situ. La impresión 3D de CFC potencializaría su aplicación al permitir cirugías reconstructivas de defectos con geometrías complejas, sin embargo, una limitante es la baja inyectabilidad de los CFC debido a la separación de fases que ocurre durante la inyección de la pasta. En este trabajo se ha estudiado la implementación de un polímero termosensible como el Poloxámero 407 para generar una tinta inyectable. Dicha tinta ha sido formulada para contener 5 % de hidroxiapatita carbonatada tipo B como agente nucleante biocompatible y biodegradable. Se evaluaron adiciones de soluciones acuosas de Poloxámero 407 al 0 %, 20 % y 40 % en peso como fase gel a una relación líquido/polvo de 0,75 mL/g. Se determinó el coeficiente de inyectabilidad, la cohesión de las tintas y se caracterizó la resistencia a la compresión de los cementos empleando análisis Weibull, determinado que la adición de polímero disminuye las propiedades mecánicas de los CFC en un 52,68 % y 81,23 %, respectivamente, en relación con el CFC de control (0%), atribuido a una menor densificación del cemento. Se concluyó que las adiciones del Poloxámero 407 no interfieren en la precipitación de hidroxiapatita deficiente en calcio ni en la degradación in vitro de los cementos y favorece el comportamiento de la tinta para su posible implementación en impresión 3D.es-ES
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dc.identifierhttps://revistas.itm.edu.co/index.php/tecnologicas/article/view/2276
dc.identifier10.22430/22565337.2276
dc.identifier.urihttps://hdl.handle.net/20.500.12622/7818
dc.languagespa
dc.publisherInstituto Tecnológico Metropolitano (ITM)es-ES
dc.relationhttps://revistas.itm.edu.co/index.php/tecnologicas/article/view/2276/2394
dc.relationhttps://revistas.itm.edu.co/index.php/tecnologicas/article/view/2276/2397
dc.relationhttps://revistas.itm.edu.co/index.php/tecnologicas/article/view/2276/2398
dc.relationhttps://revistas.itm.edu.co/index.php/tecnologicas/article/view/2276/2412
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dc.rightsDerechos de autor 2022 TecnoLógicases-ES
dc.sourceTecnoLógicas; Vol. 25 No. 53 (2022); e2276en-US
dc.sourceTecnoLógicas; Vol. 25 Núm. 53 (2022); e2276es-ES
dc.source2256-5337
dc.source0123-7799
dc.subjectCalcium phosphate cement inksen-US
dc.subjectextrusion three-dimensional printingen-US
dc.subjectinjectabilityen-US
dc.subjectpoloxamer 407en-US
dc.subjecttricalcium phosphateen-US
dc.subjectImpresión tridimensional por extrusiónes-ES
dc.subjectinyectabilidades-ES
dc.subjectfosfato tricálcicoes-ES
dc.subjectpoloxámero 407es-ES
dc.subjecttintas de cemento de fosfato de calcioes-ES
dc.titleCharacterization of Calcium Phosphate Cement Inks with Added Poloxamer 407 for Potential Application in 3D Printingen-US
dc.titleCaracterización de tintas de cemento de fosfato de calcio con adición de Poloxámero 407 para su posible aplicación en impresión 3Des-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typeResearch Papersen-US
dc.typeArtículos de investigaciónes-ES

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