Machine Learning and Soft Sensors of Electronic Nose and Tongue Type for Cancer Detection

dc.creatorGarcía-García, Laura M.
dc.creatorVallejo, Marcela
dc.creatorDelgado-Trejos, Edilson
dc.date2025-08-22
dc.date.accessioned2025-10-01T23:53:16Z
dc.descriptionCancer has high incidence and mortality rates worldwide and early diagnosis significantly improves survival outcomes. Consequently, there is a growing interest in non-invasive and cost-effective diagnostic tools, such as soft sensors for the analysis of Volatile Organic Compounds (VOCs), which can serve as biomarkers for the disease. This article aimed to present a comprehensive review on the use of electronic noses and tongues as soft sensors for cancer detection, along with data processing through machine learning algorithms. A qualitative methodology was employed, based on a literature review of databases including ScienceDirect, IEEEXplore, Sage Journals, and Scopus, resulting in the selection of 54 relevant articles published between 2010 and 2024. The articles were selected using a process aligned with the PRISMA methodology. The findings highlight the application of soft sensors for the detection of lungs, prostate, bladder, breast, ovarian, colorectal, gastric cancers, and oral cavity conditions, using samples such as urine, exhaled breath, saliva, and blood. The discussion addresses comparative analyses of representation and decision-making techniques, as well as emerging trends, challenges, and research opportunities in the field. The study concludes that integrating soft metrology with soft sensors and machine learning enables the accurate measurement of cancer biomarkers from biological substances, achieving detection accuracies of approximately 90%. However, significant research challenges and opportunities related to system architecture optimization remain to enhance reliability.en-US
dc.descriptionEl cáncer tiene alta incidencia y mortalidad a nivel mundial, y un diagnóstico temprano mejora significativamente la supervivencia. Por ello, se buscan herramientas no invasivas y económicas, como los soft sensores, para analizar Compuestos Orgánicos Volátiles (COV) que pueden actuar como biomarcadores de la enfermedad. Este artículo tuvo como objetivo revisar el estado del arte sobre el uso de narices y lenguas electrónicas como soft sensores para la detección de cáncer, junto con el procesamiento de datos mediante máquinas de aprendizaje. Se empleó una metodología cualitativa basada en la revisión de literatura científica publicada en bases de datos como ScienceDirect, IEEEXplore, Sage Journals y Scopus. Se seleccionaron 54 artículos relevantes, a partir de un proceso basado en la metodología PRISMA, publicados entre 2010 y 2024. Los resultados revelaron el uso de soft sensores para detectar cáncer de pulmón, próstata, vejiga, mama, ovario, colon, estómago y cavidad bucal, utilizando muestras como orina, aliento, saliva y sangre. La discusión incluyó comparaciones entre técnicas de análisis y decisiones, además se destacan tendencias, desafíos y oportunidades de investigación en el área. Se concluye que combinar la soft metrología, los soft sensores y el aprendizaje automático permite detectar biomarcadores del cáncer con una precisión alrededor del 90 %. No obstante, aún existen retos y oportunidades de investigación para optimizar las arquitecturas y lograr sistemas más confiables.es-ES
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dc.identifierhttps://revistas.itm.edu.co/index.php/tecnologicas/article/view/3296
dc.identifier10.22430/22565337.3296
dc.identifier.urihttps://hdl.handle.net/20.500.12622/7935
dc.languagespa
dc.publisherInstituto Tecnológico Metropolitano (ITM)es-ES
dc.relationhttps://revistas.itm.edu.co/index.php/tecnologicas/article/view/3296/3720
dc.relationhttps://revistas.itm.edu.co/index.php/tecnologicas/article/view/3296/3786
dc.relationhttps://revistas.itm.edu.co/index.php/tecnologicas/article/view/3296/3787
dc.relation/*ref*/Organización Mundial de la Salud (OMS), “Cáncer,” who.int. Accessed: May. 08. 2023. [Online]. Available: https://www.who.int/es/news-room/fact-sheets/detail/cancer
dc.relation/*ref*/H. Sung et al., “Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries,” CA Cancer J. Clin., vol. 71, no. 3, pp. 209–249, May. 2021. https://doi.org/10.3322/caac.21660
dc.relation/*ref*/N. Rodríguez Hernández, T. Romero Pérez, M. L. López Prieto, C. A. Cobas Santos, and Y. Martínez Carmona, “Nivel de conocimiento sobre exámenes diagnósticos para la detección precoz del cáncer colorrectal,” Rev. Cien. Méd. Pinar del Río, vol 23, no. 2, pp. 286–294, Mar. 2019. http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1561-31942019000200286
dc.relation/*ref*/H. Amal et al., “Breath testing as potential colorectal cancer screening tool,” Int. J. Cancer, vol. 138, no. 1, pp. 229–236, Jan. 2016. https://doi.org/10.1002/ijc.29701
dc.relation/*ref*/S. Chandrapalan, and R. P. Arasaradnam, “Urine as a biological modality for colorectal cancer detection,” Expert Rev. Mol. Diagn., vol. 20, no. 5, pp. 489–496, Mar. 2020. https://doi.org/10.1080/14737159.2020.1738928
dc.relation/*ref*/M. Vallejo, N. Bahamón, L. Rossi, and E. Delgado-Trejos, “Handbook of Metrology and Applications,” in Soft Metrology: Concept and Challenges from Uncertainty Estimation, D. K. Aswal, S. Yadav, T. Takatsuji, P. Rachakonda, and H. Kumar, Eds., Singapore: Springer, 2023, pp. 1–31. https://doi.org/10.1007/978-981-19-1550-5_67-1
dc.relation/*ref*/Y. Li, X. Wei, Y. Zhou, J. Wang, and R. You, “Research progress of electronic nose technology in exhaled breath disease analysis,” Microsyst. Nanoeng., vol. 9, no. 1, p. 129, Oct. 2023. https://doi.org/10.1038/s41378-023-00594-0
dc.relation/*ref*/L. Pascual et al., “Detection of prostate cancer using a voltammetric electronic tongue,” Analyst, vol. 141, no. 15, pp. 4562–4567, Aug. 2016. https://doi.org/10.1039/c6an01044j
dc.relation/*ref*/M. Alamin Talukder, M. Manowarul Islam, M. Ashraf Uddin, A. Akhter, K. Fida Hasan, and M. Ali Moni, “Machine learning-based lung and colon cancer detection using deep feature extraction and ensemble learning,” Expert Syst. Appl., vol. 205, p. 117695, Nov. 2022. https://doi.org/10.1016/j.eswa.2022.117695
dc.relation/*ref*/D. C. Braz et al., “Using machine learning and an electronic tongue for discriminating saliva samples from oral cavity cancer patients and healthy individuals,” Talanta, vol. 243, p. 123327, Jun. 2022. https://doi.org/10.1016/j.talanta.2022.123327
dc.relation/*ref*/J. Fitzgerald, and H. Fenniri, “Cutting edge methods for non-invasive disease diagnosis using e-tongue and e-nose devices,” Biosensors, vol. 7, no. 4, p. 59, Dec. 2017. https://doi.org/10.3390/bios7040059
dc.relation/*ref*/Z. Zhang et al., “Electronic nose based on metal oxide semiconductor sensors for medical diagnosis,” Progress Nat. Sci.: Mater. Int., vol. 34, no. 1, pp. 74–88, Feb. 2024. https://doi.org/10.1016/j.pnsc.2024.01.018
dc.relation/*ref*/E. G. M. Steenhuis et al., “Feasibility of volatile organic compound in breath analysis in the follow-up of colorectal cancer: A pilot study,” Eur. J. Surg. Oncol., vol. 46, no. 11, pp. 2068–2073, Nov. 2020. https://doi.org/10.1016/j.ejso.2020.07.028
dc.relation/*ref*/D. F. Altomare et al., “The use of the PEN3 e-nose in the screening of colorectal cancer and polyps,” Tech. Coloproctol., vol. 20, no. 6, pp. 405–409, Jun. 2016. https://doi.org/10.1007/s10151-016-1457-z
dc.relation/*ref*/K. E. Van Keulen, M. E. Jansen, R. W. M. Schrauwen, J. J. Kolkman, and P. D. Siersema, “Volatile organic compounds in breath can serve as a non-invasive diagnostic biomarker for the detection of advanced adenomas and colorectal cancer,” Aliment. Pharmacol. Ther., vol. 51, no. 3, pp. 334–346, Feb. 2020 https://doi.org/10.1111/apt.15622
dc.relation/*ref*/R. Thriumani et al., “Cancer detection using an electronic nose: A preliminary study on detection and discrimination of cancerous cells,” in IECBES 2014, Conf. Proc. - 2014 IEEE Conf. Biomed. Engin. Sci., Kuala Lumpur, Malay, 2014, pp. 752–756. https://doi.org/10.1109/IECBES.2014.7047609
dc.relation/*ref*/K. Chen et al., “Recognizing lung cancer and stages using a self-developed electronic nose system,” Comput. Biol. Med., vol. 131, p. 104294, Apr. 2021. https://doi.org/10.1016/j.compbiomed.2021.104294
dc.relation/*ref*/J.-M. Lee et al., “A DNA-derived phage nose using machine learning and artificial neural processing for diagnosing lung cancer,” Biosens. Bioelectron., vol. 194, p. 113567, Dec. 2021. https://doi.org/10.1016/j.bios.2021.113567
dc.relation/*ref*/B. Liu et al., “Lung cancer detection via breath by electronic nose enhanced with a sparse group feature selection approach,” Sens. Actuators B Chem., vol. 339, p. 129896. Jul. 2021. https://doi.org/10.1016/j.snb.2021.129896
dc.relation/*ref*/J. Qian, F. Tian, Y. Luo, M. Lu, and A. Zhang, “A Novel Multisensor Detection System Design for Low Concentrations of Volatile Organic Compounds,” IEEE Transact. Ind. Electr., vol. 69, no. 5, pp. 5314–5324, May. 2022. https://doi.org/10.1109/TIE.2021.3080218
dc.relation/*ref*/T. Saidi et al., “Non-invasive prediction of lung cancer histological types through exhaled breath analysis by UV-irradiated electronic nose and GC/QTOF/MS,” Sens. Actuators B: Chem., vol. 311, p. 127932, May. 2020. https://doi.org/10.1016/j.snb.2020.127932
dc.relation/*ref*/M. Tirzïte, M. Bukovskis, G. Strazda, N. Jurka, and I. Taivans, “Detection of lung cancer with electronic nose and logistic regression analysis,” J. Breath Res., vol. 13, no. 1, Nov. 2019. https://doi.org/10.1088/1752-7163/aae1b8
dc.relation/*ref*/V. A. Binson, M. Subramoniam, and L. Mathew, “Detection of COPD and Lung Cancer with electronic nose using ensemble learning methods,” Clin. Chimica Acta, vol. 523, pp. 231–238, Dec. 2021. https://doi.org/10.1016/j.cca.2021.10.005
dc.relation/*ref*/R. Van de Goor, M. Van Hooren, A. M. Dingemans, B. Kremer, and K. Kross, “Training and Validating a Portable Electronic Nose for Lung Cancer Screening,” J. Thorac. Oncol., vol. 13, no. 5, pp. 676–681, May. 2018. https://doi.org/10.1016/j.jtho.2018.01.024
dc.relation/*ref*/X. Zhan, Z. Wang, M. Yang, Z. Luo, Y. Wang, and G. Li, “An electronic nose-based assistive diagnostic prototype for lung cancer detection with conformal prediction,” Measur., vol. 158, p. 107588, Jul. 2020. https://doi.org/10.1016/j.measurement.2020.107588
dc.relation/*ref*/G. Rocco et al., “A Real-World Assessment of Stage I Lung Cancer Through Electronic Nose Technology,” J. Thorac. Oncol., vol. 19, no. 9, pp. 1272–1283, Sep. 2024. https://doi.org/10.1016/j.jtho.2024.05.006
dc.relation/*ref*/A. Zompanti et al., “Sensor technology advancement enhancing exhaled breath portability: Device set up and pilot test in the longitudinal study of lung cancer,” Sens. Actuators B: Chem., vol. 423, p. 136735, Jan. 2025. https://doi.org/10.1016/j.snb.2024.136735
dc.relation/*ref*/H. Xiong et al., “Recent advances in biosensors detecting biomarkers from exhaled breath and saliva for respiratory disease diagnosis,” Biosens. Bioelectron., vol. 267, p. 116820, Jan. 2025. https://doi.org/10.1016/j.bios.2024.116820
dc.relation/*ref*/V. Chaudhary et al., “Nose-on-Chip Nanobiosensors for Early Detection of Lung Cancer Breath Biomarkers,” ACS Sens., vol. 9, no. 9, pp. 4469–4494, Sep. 2024. https://doi.org/10.1021/acssensors.4c01524
dc.relation/*ref*/V. N. E. Schuermans et al., “Pilot Study: Detection of Gastric Cancer from Exhaled Air Analyzed with an Electronic Nose in Chinese Patients,” Surg. Innov., vol. 25, no. 5, pp. 429–434, Jun. 2018. https://doi.org/10.1177/1553350618781267
dc.relation/*ref*/I. Polaka, E. Gašenko, O. Barash, H. Haick, and M. Leja, “Constructing Interpretable Classifiers to Diagnose Gastric Cancer Based on Breath Tests,” Procedia Comp. Sci., vol. 104, pp. 279–285, 2017. https://doi.org/10.1016/j.procs.2017.01.136
dc.relation/*ref*/R. Angioli et al., “Use of Sensor Array Analysis to Detect Ovarian Cancer through Breath, Urine, and Blood: A Case-Control Study,” Diagnostics, vol. 14, no. 5, p. 561, Mar. 2024. https://doi.org/10.3390/diagnostics14050561
dc.relation/*ref*/P. Bassi et al., “Improved non-invasive diagnosis of bladder cancer with an electronic nose: A large pilot study,” J. Clin. Med., vol. 10, no. 21, p. 4984, Nov. 2021. https://doi.org/10.3390/jcm10214984
dc.relation/*ref*/C. Bax, L. Capelli, F. Grizzi, S. Prudenza, and G. Taverna, “A novel approach for the non-invasive diagnosis of prostate cancer based on urine odour analysis,” in 2022 IEEE Int. Symp. Olfact. Electr. Nose (ISOEN), Aveiro, Portugal, 2022, pp. 1–4. https://doi.org/10.1109/isoen54820.2022.9789651
dc.relation/*ref*/A. Filianoti et al., “Volatilome Analysis in Prostate Cancer by Electronic Nose: A Pilot Monocentric Study,” Cancers (Basel), vol. 14, no. 12, p. 2927, Jun. 2022. https://doi.org/10.3390/cancers14122927
dc.relation/*ref*/G. Taverna et al., “Accuracy of a new electronic nose for prostate cancer diagnosis in urine samples,” Int. J. Urol., vol. 29, no. 8, pp. 890-893, Aug. 2022. https://doi.org/10.1111/iju.14912
dc.relation/*ref*/H. Heers et al., “VOC‐based detection of prostate cancer using an electronic nose and ion mobility spectrometry: A novel urine‐based approach,” Prostate, vol. 84, no. 8, pp. 756–762, Jun. 2024. https://doi.org/10.1002/pros.24692
dc.relation/*ref*/H. Tyagi, E. Daulton, A. S. Bannaga, R. P. Arasaradnam, and J. A. Covington, “Non-Invasive Detection and Staging of Colorectal Cancer Using a Portable Electronic Nose,” Sensors, vol. 21, no. 16, p. 5440, Aug. 2021. https://doi.org/10.3390/s21165440
dc.relation/*ref*/E. Westenbrink et al., “Development and application of a new electronic nose instrument for the detection of colorectal cancer,” Biosens. Bioelectron., vol. 67, pp. 733–738, May. 2015. https://doi.org/10.1016/j.bios.2014.10.044
dc.relation/*ref*/J. Monreal-Trigo et al., “New bladder cancer non-invasive surveillance method based on voltammetric electronic tongue measurement of urine,” iScience, vol. 25, no. 9, p. 104829, Sep. 2022. https://doi.org/10.1016/j.isci.2022.104829
dc.relation/*ref*/R. Belugina, E. Karpushchenko, A. Sleptsov, V. Protoshchak, A. Legin, and D. Kirsanov, “Developing non-invasive bladder cancer screening methodology through potentiometric multisensor urine analysis,” Talanta, vol. 234, p. 122696, Nov. 2021. https://doi.org/10.1016/j.talanta.2021.122696
dc.relation/*ref*/D. Lin et al., “Colorectal cancer detection by gold nanoparticle based surface-enhanced Raman spectroscopy of blood serum and statistical analysis,” Opt. Express, vol. 19, no. 14, pp. 13565-13577, Jul. 2011. https://doi.org/10.1364/OE.19.013565
dc.relation/*ref*/S. Feng et al., “Nasopharyngeal cancer detection based on blood plasma surface-enhanced Raman spectroscopy and multivariate analysis,” Biosens. Bioelectron., vol. 25, no. 11, pp. 2414–2419, Jul. 2010. https://doi.org/10.1016/j.bios.2010.03.033
dc.relation/*ref*/C. M. Durán Acevedo, J. K. Carrillo Gómez, C. A. Cuastumal Vasquez, and J. Ramos, “Prostate Cancer Detection in Colombian Patients through E-Senses Devices in Exhaled Breath and Urine Samples,” Chemosen., vol. 12, no. 1, p. 11, Jan. 2024. https://doi.org/10.3390/chemosensors12010011
dc.relation/*ref*/S. Solovieva et al., “Potentiometric multisensor system as a possible simple tool for non-invasive prostate cancer diagnostics through urine analysis,” Sens. Actuators B Chem., vol. 289, pp. 42–47, Jun. 2019. https://doi.org/10.1016/j.snb.2019.03.072
dc.relation/*ref*/M. Mahdi Bordbar et al., “A colorimetric electronic tongue based on bi-functionalized AuNPs for fingerprint detection of cancer markers,” Sens. Actuators B Chem., vol. 368, p. 132170, Oct. 2022. https://doi.org/10.1016/j.snb.2022.132170
dc.relation/*ref*/D. Tibaduiza et al., “Electronic Tongues and Noses: A General Overview,” Biosens., vol. 14, no. 4, p. 190, Apr. 2024. https://doi.org/10.3390/bios14040190
dc.relation/*ref*/J. Rana, and S. Desai, “Recent advances in e-nose for potential applications in Covid-19 infection,” Talanta Open, vol. 10, p. 100363, Dec. 2024. https://doi.org/10.1016/j.talo.2024.10036
dc.relation/*ref*/M.-R. Lee et al., “Cross-site validation of lung cancer diagnosis by electronic nose with deep learning: a multicenter prospective study,” Respir. Res., vol. 25, no. 1, p. 203, May. 2024. https://doi.org/10.1186/s12931-024-02840-z
dc.relation/*ref*/K.-C. Chen, S.-W. Kuo, R.-H. Shie, and H.-Y. Yang, “Advancing accuracy in breath testing for lung cancer: strategies for improving diagnostic precision in imbalanced data,” Respir. Res., vol. 25, no. 1, p. 32, Jan. 2024. https://doi.org/10.1186/s12931-024-02668-7
dc.relation/*ref*/S. Kort et al., “Diagnosing Non-Small Cell Lung Cancer by Exhaled Breath Profiling Using an Electronic Nose,” Chest, vol. 163, no. 3, pp. 697–706, Mar. 2023. https://doi.org/10.1016/j.chest.2022.09.042
dc.relation/*ref*/Y. Saeki et al., “Lung cancer detection in perioperative patients’ exhaled breath with nanomechanical sensor array,” Lung Cancer, vol. 190, p. 107514, Apr. 2024. https://doi.org/10.1016/j.lungcan.2024.107514
dc.relation/*ref*/V. A. Binson, M. Subramoniam, and L. Mathew, “Prediction of lung cancer with a sensor array based e-nose system using machine learning methods,” Microsyst. Technol., vol. 30, no. 11, pp. 1421–1434, Nov. 2024. https://doi.org/10.1007/s00542-024-05656-5
dc.relation/*ref*/L. Zhao et al., “A Weighted Discriminative Extreme Learning Machine Design for Lung Cancer Detection by an Electronic Nose System,” IEEE Trans. Instrum. Meas., vol. 70, no. 2509709, pp. 1–9, May. 2021. https://doi.org/10.1109/TIM.2021.3084312
dc.relation/*ref*/S. Zhang, J. Luo, and M. Lu, “Study on Repeatability, Normalization and Feature Selection of Medical Electronic Nose for Lung Cancer Diagnosis,” in 2020 IEEE 10th Int. Conf. Electr. Infor. Emerg. Communic. (ICEIEC), Beijing, Chi, 2020, pp. 358–361. https://doi.org/10.1109/ICEIEC49280.2020.9152322
dc.relation/*ref*/S. Zhang et al., “A Universal Calibration Method for Electronic Nose Based on Projection on to Convex Sets,” IEEE Trans. Instrum. Meas., vol. 70, no. 2516012, pp. 1–12, Oct. 2021. https://doi.org/10.1109/TIM.2021.3120149
dc.relation/*ref*/A. Helen Victoria, and G. Maragatham, “Automatic tuning of hyperparameters using Bayesian optimization,” Evolving Systems, vol. 12, no. 1, pp. 217–223, Mar. 2021. https://doi.org/10.1007/s12530-020-09345-2
dc.relation/*ref*/D. Theng, and K. K. Bhoyar, “Feature selection techniques for machine learning: a survey of more than two decades of research,” Knowl. Inf. Syst., vol. 66, pp. 1575–1637, Mar. 2023. https://doi.org/10.1007/s10115-023-02010-5
dc.relation/*ref*/G. Simon, and C. Aliferis, “Overfitting, Underfitting and General Model Overconfidence and Under-Performance Pitfalls and Best Practices in Machine Learning and AI,” in Artificial Intelligence and Machine Learning in Health Care and Medical Sciences, G. Simon and C. Aliferis, Eds., Minneapolis, USA: Springer, 2024, pp. 477-524. https://doi.org/10.1007/978-3-031-39355-6_10
dc.relation/*ref*/C. Shang, F. Yang, D. Huang, and W. Lyu, “Data-driven soft sensor development based on deep learning technique,” J. Process Control, vol. 24, no. 3, pp. 223–233, Mar. 2014. https://doi.org/10.1016/j.jprocont.2014.01.012
dc.relation/*ref*/Y. Xu, L. Ju, J. Tong, C. M. Zhou, and J.-J. Yang, “Machine Learning Algorithms for Predicting the Recurrence of Stage IV Colorectal Cancer After Tumor Resection,” Sci. Rep., vol. 10, no. 1, p. 2519, Feb. 2020. https://doi.org/10.1038/s41598-020-59115-y
dc.relation/*ref*/
dc.rightsDerechos de autor 2025 TecnoLógicases-ES
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/4.0es-ES
dc.sourceTecnoLógicas; Vol. 28 No. 63 (2025); e3296en-US
dc.sourceTecnoLógicas; Vol. 28 Núm. 63 (2025); e3296es-ES
dc.source2256-5337
dc.source0123-7799
dc.subjectcompuestos orgánicos volátileses-ES
dc.subjectdiagnóstico no invasivoes-ES
dc.subjectespacio de representaciónes-ES
dc.subjectsoft metrologíaes-ES
dc.subjecttécnicas de aprendizajees-ES
dc.subjectvolatile organic compoundsen-US
dc.subjectnon-invasive diagnosisen-US
dc.subjectfeature spaceen-US
dc.subjectsoft metrologyen-US
dc.subjectlearning techniquesen-US
dc.titleMachine Learning and Soft Sensors of Electronic Nose and Tongue Type for Cancer Detectionen-US
dc.titleMáquinas de aprendizaje y soft sensores de tipo nariz y lengua electrónica para la detección de cánceres-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typeReview Articleen-US
dc.typeArtículos de revisiónes-ES

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