Eco-Pharmacovigilance at the Water–Health Interface: Mechanistic Ecotoxicology for One Health in the Age of Mixtures
| dc.creator | Gómez-Oliván, Leobardo Manuel | |
| dc.date | 2026-04-22 | |
| dc.date.accessioned | 2026-05-26T16:18:38Z | |
| dc.description | Medicines are designed to be biologically active in low doses, and their biological “afterlife” often continues beyond the patient and beyond the clinic. Pharmacovigilance was created to detect, assess, understand, and prevent adverse effects and other medicine-related problems in patients. Ecopharmacovigilance extends that vigilance to environmental compartments, where pharmaceuticals and their residues enter ecosystems through excretion, disposal, and effluent pathways. Looking through the lens of One Health, this is not a peripheral issue: the health of people, animals, and ecosystems is coupled through shared water, food, and environments. | en-US |
| dc.description | Los medicamentos están diseñados para ser biológicamente activos en dosis bajas, y su “vida posterior” biológica a menudo continúa más allá del paciente y de la clínica. La farmacovigilancia se creó para detectar, evaluar, comprender y prevenir los efectos adversos y otros problemas relacionados con los medicamentos en los pacientes. La ecofarmacovigilancia extiende esa vigilancia a los compartimentos ambientales, donde los productos farmacéuticos y sus residuos ingresan a los ecosistemas a través de la excreción, la eliminación y las vías de efluentes. Desde la perspectiva de Una Salud, este no es un problema periférico: la salud de las personas, los animales y los ecosistemas está interconectada a través del agua, los alimentos y los entornos compartidos. | es-ES |
| dc.format | application/pdf | |
| dc.identifier | https://revistas.itm.edu.co/index.php/tecnologicas/article/view/3982 | |
| dc.identifier | 10.22430/22565337.3982 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12622/8155 | |
| dc.language | eng | |
| dc.publisher | Instituto Tecnológico Metropolitano (ITM) | en-US |
| dc.relation | https://revistas.itm.edu.co/index.php/tecnologicas/article/view/3982/4056 | |
| dc.relation | /*ref*/[World Health Organization, “Regulation and Prequalification,” World Health Organization. Accessed: Feb. 2, 2026. [Online.] Available: https://www.who.int/teams/regulation-prequalification/regulation-and-safety/pharmacovigilance | |
| dc.relation | /*ref*/B. Medhi, and Rakesh K. Sewal, “Ecopharmacovigilance: An issue urgently to be addressed,” Indian J. Pharmacol., vol. 44, no. 5, pp. 547–549, Sep.-Oct. 2012. https://doi.org/10.4103/0253-7613.100363 | |
| dc.relation | /*ref*/C. G. Daughton, and I. S. Ruhoy, “The afterlife of drugs and the role of pharmEcovigilance,” Drug Saf., vol. 31, no. 12, pp. 1069–1082, Dec. 2008. https://doi.org/10.2165/0002018-200831120-00004 | |
| dc.relation | /*ref*/Food and Agriculture Organization of the United Nations et al., “Tripartite and UNEP support OHHLEP’s definition of ‘One Health’,” Joint News Release, 2021. Accessed: Feb. 2, 2026. [Online]. Available: https://www.who.int/news/item/01-12-2021-tripartite-and-unep-support-ohhlep-s-definition-of-one-health | |
| dc.relation | /*ref*/L. M. Gómez-Oliván, “Integrative Ecotoxicology of Pharmaceuticals and Nanoplastics: A PRISMA-Guided Bibliometric Review Linking Ecosystem and Environmental Health,” Earth: Environ. Sustain., vol. 1, no. 2, pp. 322–342, Nov. 2025. https://doi.org/10.53941/eesus.2025.100025 | |
| dc.relation | /*ref*/I. Casas-Hinojosa et al., “Environmental caffeine triggers oxidative stress and behavioral changes in Cyprinus carpio: Insights into neurotoxicity,” Behav. Brain Res., vol. 493, p. 115695, Sep. 2025. https://doi.org/10.1016/j.bbr.2025.115695 | |
| dc.relation | /*ref*/J. M. Orozco-Hernández et al., “Toxic interactions between fluoxetine and microplastics in zebrafish embryonic development,” Sci. Total Environ., vol. 970, p. 179040, Mar. 2025. https://doi.org/10.1016/j.scitotenv.2025.179040 | |
| dc.relation | /*ref*/N. SanJuan-Reyes et al., “Linking contaminant levels in Tepetitlán reservoir to zebrafish (Danio rerio) embryotoxicity and gene expression responses,” J. Contam. Hydrol., vol. 275, p. 104690, Nov. 2025. https://doi.org/10.1016/j.jconhyd.2025.104690 | |
| dc.relation | /*ref*/K. Ruiz-Lara et al., “Human health risk assessment by exposure to contaminants from an urban reservoir: a pilot study in the Madin Dam (México),” Environ. Monit. Assess., vol. 197, no 2, p. 193, Jan. 2025. https://doi.org/10.1007/s10661-025-13640-3 | |
| dc.relation | /*ref*/G. A. Elizalde-Velázquez et al., “Assessing cisplatin-induced acute toxicity in zebrafish (Danio rerio): a multi-organ perspective at realistic concentrations,” Environ. Sci. Pollut. Res. Int., vol. 32, no. 24, pp. 14659–14672, 2025. https://doi.org/10.1007/s11356-025-36549-3 | |
| dc.relation | /*ref*/Elizalde-Velázquez et al., “Locomotor activity alterations in zebrafish following cisplatin exposure: An assessment of neurobehavioral toxicity,” Sci. Total Environ., vol. 985, p. 179776, Jul. 2025. https://doi.org/10.1016/j.scitotenv.2025.179776 | |
| dc.relation | /*ref*/G. A. Elizalde-Velázquez et al., “Detrimental impact of photo-Fenton treated COVID-19 drugs on liver function: A thorough investigation in Danio rerio,” J. Environ. Manage., vol. 381, p. 125182, May. 2025. https://doi.org/10.1016/j.jenvman.2025.125182 | |
| dc.relation | /*ref*/G. A. Elizalde-Velázquez et al., “Neurotoxic potential of imatinib in aquatic vertebrates: Behavioral and biochemical disruptions in zebrafish,” Neurotoxicology, vol. 111, p. 103352, Dec. 2025. https://doi.org/10.1016/j.neuro.2025.103352 | |
| dc.relation | /*ref*/J. M. Orozco-Hernández et al., “Behavioral alterations in adult zebrafish induced by venlafaxine: correlation with oxidative stress, gene expression, and brain histopathological damage,” Environ. Res., vol. 276, p. 121550, Jul. 2025. https://doi.org/10.1016/j.envres.2025.121550 | |
| dc.relation | /*ref*/L. M. Sanchez-Aceves et al., “Multilevel neurotoxicity of venlafaxine in zebrafish: Behavioral impairment, biomolecular dysregulation, and brain tissue damage,” Environ. Res., vol. 285, p. 122328, Nov. 2025. https://doi.org/10.1016/j.envres.2025.122328 | |
| dc.relation | /*ref*/K. Saucedo-Vence et al., “Effect of emerging contaminants (sucralose) at relevant concentrations on functional properties in fish muscle of common carp (Cyprinus carpio),” Foods, vol. 14, no. 19, p. 3387, Sep. 2025. https://doi.org/10.3390/foods14193387 | |
| dc.relation | /*ref*/F. Chen, Y. Xia, H. O. Elansary, y L. M. Gómez Oliván, “Human risk assessment of lead toxicity in maize: a novel approach using TiO2- and MgO-nanoparticles,” Environ. Sci. Nano, vol. 12, no. 6, pp. 3301–3316, 2025. https://doi.org/10.1039/D4EN00992D | |
| dc.relation | /*ref*/L. M. Gómez-Oliván et al., “Design and validation of an environmental literacy tool for Mexican schoolchildren: guiding curriculum-based interventions on water conservation, recycling, solid waste management, and medication disposal,” Environ. Sci. Pollut. Res. Int., vol. 32, no. 47, pp. 27299–27310, Oct. 2025. https://doi.org/10.1007/s11356-025-37231-4 | |
| dc.rights | Copyright (c) 2026 TecnoLógicas | en-US |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/4.0 | en-US |
| dc.source | TecnoLógicas; Vol. 29 No. 65 (2026); e3982 | en-US |
| dc.source | TecnoLógicas; Vol. 29 Núm. 65 (2026); e3982 | es-ES |
| dc.source | 2256-5337 | |
| dc.source | 0123-7799 | |
| dc.subject | mezclas contaminantes | es-ES |
| dc.subject | toxicidad acuática | es-ES |
| dc.subject | biomarcadores moleculares | es-ES |
| dc.subject | exposición ambiental crónica | es-ES |
| dc.subject | evaluación de riesgos ambientales | es-ES |
| dc.subject | contaminant mixtures | en-US |
| dc.subject | aquatic toxicity | en-US |
| dc.subject | molecular biomarkers | en-US |
| dc.subject | chronic environmental exposure | en-US |
| dc.subject | environmental risk assessment | en-US |
| dc.title | Eco-Pharmacovigilance at the Water–Health Interface: Mechanistic Ecotoxicology for One Health in the Age of Mixtures | en-US |
| dc.title | Ecofarmacovigilancia en la interfaz agua-salud: ecotoxicología mecanicista para una sola salud en la era de las mezclas | es-ES |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:eu-repo/semantics/publishedVersion | |
| dc.type | Editorial | en-US |
| dc.type | Editorial | es-ES |
Archivos
Bloque original
1 - 1 de 1