Publicación:
Desarrollo de plataforma de biosensado basado en antenas microstrip para detección de cáncer

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dc.contributor.advisorReyes Vera, Erick
dc.contributor.advisorMontoya Villada, Sebastian
dc.contributor.authorLara Davila, Natalia Carolina
dc.date.accessioned2026-05-29T16:14:04Z
dc.date.available2023
dc.date.issued2023-10-23
dc.description.abstractEn las últimas décadas el uso de transductores ha sido ampliamente explorados para el estudio de diversos componentes biológicos, con el fin de detectar con precisión la presencia de biomarcadores específicos relacionados a uno o varios tipos de cánceres. En especial, los sensores basados en tecnologia microstrip han sido una alternativa ampliamente explorada en los últimos años, esto, debido a que son dispositivos no invasivos, sensibles, de fácil fabricación y bajos costos. Por lo anterior, en este trabajo, se llevó a cabo el estudio, diseño, fabricación y validación experimental de un sensor de microondas capaz de medir los cambios en frecuencia asociados con variaciones en la permitividad dieléctrica de ciertas sustancias biológicas y químicas. Se optó por realizar un diseño basado en sensores de división de frecuencia, utilizando una topología de pares de resonadores de impedancia escalonada (SIR) ya que son capaces de detectar pequeñas variaciones en las propiedades dieléctricas. Además, se realizó un protocolo para la activación química y biofuncionalización de estos sensores, con el objetivo de eliminar la pasivación de las capas de óxido de los electrodos de cobre, con el propósito de mejorar su capacidad de interactuar selectivamente con las moléculas de interés para su detección y análisis. Inicialmente, se estudió el comportamiento del sensor frente a la interacción de Solución Salina Tamponada con Fosfato (PBS) con diferentes concentraciones de Albúmina Sérica Bovina (BSA). Esta proteína que se encuentra en la sangre de los bovinos y se utiliza comúnmente como marcador biológico de referencia en múltiples investigaciones. Está etapa es crucial, ya que permite establecer la sensibilidad, especificidad y límites de detección del sensor de microondas antes de utilizarlos en muestras biológicas más desterminadas por el uso de la proteína p-53, la cual es asociada a varios tipos de cáncer. Este trabajo contribuye al desarrollo de sensores de microondas eficientes y asequibles que pueden desempeñar un papel crucial en la detección temprana y precisa de variedad de biomarcadores, incluyendo aquellas relacionadas con enfermedades graves como el cáncer.spa
dc.description.degreelevelPregrado
dc.description.degreenameIngeniero(a) en Telecomunicaciones
dc.description.tableofcontents1. INTRODUCCIÓN ............................................................................................................... 7 Objetivo general ............................................................................................................................ 11 Objetivos específicos ..................................................................................................................... 11 2. MARCO TEÓRICO ........................................................................................................... 12 2.1 Tecnología microcinta. ...................................................................................................... 12 2.1.1 Configuración y principios de funcionamiento de antenas microcinta. ................... 13 2.1.2 Geometría y materiales en antenas microcinta. ....................................................... 14 2.1.3 Cálculo de impedancias de líneas de transmisión ..................................................... 17 2.2 Biosensores ....................................................................................................................... 18 2.2.1 Biosensores en la región de las microondas. ............................................................ 21 2.2.2 Sensores en la región microondas basados en resonadores de impedancia escalona (SIR) 22 2.3 Biofuncionalización de superficies. ................................................................................... 24 2.3.1 Autoensamblaje de monocapa (SAM)....................................................................... 25 2.3.2 Ligados bifuncionales. ............................................................................................... 27 3. METODOLOGÍA .............................................................................................................. 28 3.1 Diseño del sensor en la región microondas basado en Resonadores de Impedancia Escalonada (SIR). ........................................................................................................................... 28 3.2 Modelamiento Computacional del sensor propuesto. ..................................................... 30 3.3 Fabricación del prototipo. ................................................................................................. 33 3.4 Optimización de sensibilidad. ........................................................................................... 34 3.5 Biofuncionalización de superficies. ................................................................................... 35 4. RESULTADOS Y DISCUSIÓN ............................................................................................ 41 5. CONCLUSIONES, RECOMENDACIONES Y TRABAJO FUTURO ........................................ 50 REFERENCIAS ........................................................................................................................ 52 ANEXOS ................................................................................................................................. 57
dc.format.extent58 páginas
dc.format.mimetypeapplication/pdf
dc.identifier.instnameinstname:Institución Universitaria ITMspa
dc.identifier.reponamereponame:Repositorio Institucional Institución Universitaria ITMspa
dc.identifier.repourlrepourl:https://repositorio.itm.edu.cospa
dc.identifier.urihttps://hdl.handle.net/20.500.12622/8163
dc.language.isospa
dc.publisherInstitución Universitaria ITM
dc.publisher.branchCampus Fraternidad
dc.publisher.departmentDepartamento de Electrónica y Telecomunicaciones::Ingeniería de Telecomunicaciones
dc.publisher.facultyFacultad de Ingenierías
dc.publisher.placeMedellín
dc.publisher.programIngeniería de Telecomunicaciones
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.ocde2. Ingeniería y Tecnología::2B. Ingenierías Eléctrica, Electrónica e Informática::2B05. Telecomunicaciones
dc.subject.odsODS 3: Salud y bienestar. Garantizar una vida sana y promover el bienestar de todos a todas las edades
dc.subject.proposalBiosensor
dc.subject.proposalAntenas microstripspa
dc.subject.proposalCáncer de Colon
dc.subject.proposalBiofuncionalización
dc.subject.proposalMonocapa autoensamblada
dc.subject.proposalProteína p-53
dc.subject.proposalEspecificidad
dc.titleDesarrollo de plataforma de biosensado basado en antenas microstrip para detección de cáncerspa
dc.typeTrabajo de grado - Pregrado
dc.type.coarhttp://purl.org/coar/resource_type/c_7a1f
dc.type.coarversionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.contentText
dc.type.driverinfo:eu-repo/semantics/bachelorThesis
dc.type.redcolhttp://purl.org/redcol/resource_type/TP
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication

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