| dc.contributor.author | Röthlisberger, Sarah R. | |
| dc.contributor.author | Cortes, Fabián M. | |
| dc.date.accessioned | 2019-07-18T14:12:17Z | |
| dc.date.accessioned | 2019-08-14T14:28:47Z | |
| dc.date.available | 2019-07-18T14:12:17Z | |
| dc.date.available | 2019-08-14T14:28:47Z | |
| dc.date.issued | 2010-12-15 | |
| dc.identifier | https://revistas.itm.edu.co/index.php/tecnologicas/article/view/467 | |
| dc.identifier | 10.22430/22565337.467 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.12622/720 | |
| dc.description.abstract | Durante las últimas décadas una gran variedad de biomoléculas han sido propuestas como biomarcadores de diagnóstico y de predicción de severidad de enfermedades transmisibles y no transmisibles. Estudios realizados en variedad de cánceres han revelado muchos biomarcadores, como las familias Kalikreina y Metaloproteinasas, con gran potencial en el diagnóstico de cáncer, en el establecimiento del grado de cáncer, su progresión y su respuesta a las terapias. Tradicionalmente la sangre (suero) y tejido han sido las principales fuentes biológicas para el descubrimiento de biomarcadores, pero en la última década ha surgido la orina como fuente prometedora de biomarcadores de cáncer. Esta revisión se centra en dos grandes familias, la familia Kalikreina de las serina proteasas, descubiertas en suero, y la familia Metaloproteinasas de las zinc proteasas, descubiertas en la orina; las cuales son biomarcadores potenciales contra el cáncer. | spa |
| dc.format.mimetype | application/pdf | |
| dc.language.iso | eng | |
| dc.publisher | Instituto Tecnológico Metropolitano (ITM) | spa |
| dc.relation | https://revistas.itm.edu.co/index.php/tecnologicas/article/view/467/473 | |
| dc.rights | Copyright (c) 2017 Tecno Lógicas | spa |
| dc.source | 2256-5337 | |
| dc.source | 0123-7799 | |
| dc.source | TecnoLógicas; Special edition II (2010); 97-114 | eng |
| dc.source | TecnoLógicas; Edición Especial II (2010); 97-114 | spa |
| dc.subject | Biomarcadores de cáncer | spa |
| dc.subject | gen | spa |
| dc.subject | kalikreinas | spa |
| dc.subject | metaloproteinasas | spa |
| dc.subject | proteína | spa |
| dc.title | Cellular Proteases as Cancer Biomarkers: A Review | spa |
| dc.title.alternative | Cellular Proteases as Cancer Biomarkers: A Review | |
| dc.subject.keywords | Cancer biomarkers | eng |
| dc.subject.keywords | gene | eng |
| dc.subject.keywords | kallikreins | eng |
| dc.subject.keywords | metalloproteinases | eng |
| dc.subject.keywords | protein. | eng |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:eu-repo/semantics/publishedVersion | |
| dc.type | Articles | eng |
| dc.type | Artículos | spa |
| dc.relation.ispartofjournal | TecnoLógicas | |
| dc.description.abstractenglish | Over the past few decades a variety of biomolecules have been proposed as diagnostic biomarkers and predictors of severity for transmissible and nontransmissible diseases. Studies in a range of cancers have revealed many biomarkers with great potential in cancer diagnosis, in establishing tumor stage, progression, and response to therapies; such as the Kallikrein and Metalloproteinase families. Traditionally blood (serum) and tissue have been the main biological sources of biomarker discovery, but in the past decade urine has emerged as a promising source of cancer biomarkers. In this review we will focus on two large families, the Kallikrein family of serine proteases discovered in serum, and the Metalloproteinase family of zinc proteases discovered in urine, as potential cancer biomarkers. | eng |
| dc.rights.accessrights | info:eu-repo/semantics/openAccess | |
| dc.type.coar | http://purl.org/coar/resource_type/c_6501 | |
